Scientific advances have elucidated the role of the sigma-2 receptor as a regulator of the cellular stress response, and recently as a target of the SARS-CoV-2 virus. Sigma-2 ligands, therefore, may have potential to treat conditions that share pathological disruptions in autophagy, lipid metabolism and related pathways. View pre-recorded presentations by expert speakers from the global sigma-2 community as well as Q&A recording during the live event held January 13th and 14th, 2021. On January 15th, the panelists returned for a discussion of the evolving nomenclature surrounding the sigma-2 receptor and its associated proteins.